Pengaruh pemberian ekstrak Lidah Buaya (Aloe Vera) terhadap penurunan kadar glukosa darah pada Mencit (Mus Musculus) diabetes melitus
DOI:
https://doi.org/10.54957/ijhs.v5i4.1643Kata Kunci:
Diabetes mellitus, herbal extract, blood glucose, aloe vera, miceAbstrak
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to insulin resistance and pancreatic β-cell dysfunction. One non-pharmacological treatment approach considered safe, economical, and free from harmful side effects is the use of herbal plants, such as aloe vera (Aloe vera). This plant contains active compounds such as acemannan, flavonoids, and anthraquinones that have the potential to act as antihyperglycemic agents. This study aims to investigate the effect of Aloe vera extract administration on blood glucose levels in diabetic mice (Mus musculus). This study is an experimental laboratory study using a post-test only control group design. A total of 30 male mice were used, divided into five groups: positive control, negative control, and three treatment groups with aloe vera extract doses of 250 mg/kgBB, 300 mg/kgBB, and 350 mg/kgBB, respectively. Diabetes mellitus was induced using streptozotocin (STZ) at a dose of 150 mg/kgBB. Bivariate analysis was performed using a One-Way ANOVA test with a Post-Hoc LSD test. The results showed that aloe vera extract significantly reduced blood glucose levels (p<0.05), particularly at the 350 mg/kgBB dose. Therefore, it can be concluded that aloe vera extract has the potential to effectively reduce blood glucose levels in diabetic mice, especially at the highest dose tested. This study supports the potential of aloe vera as an antidiabetic phytopharmaceutical agent.
Referensi
Arif, T., & Solikhah, F. K. (2023). Perbedaan Dua Dosis Ekstrak Lidah Buaya terhadap Glukosa Darah Tikus Diabetes Mellitus. Jurnal Keperawatan, 21(1), 9–21. https://doi.org/10.35874/jkp.v21i1.1130
Dinas Kesehatan Provinsi Sultra. (2022). Profil Kesehatan Provinsi Sulawesi Tenggara Tahun 2021. Kendari: Dinas Kesehatan Provinsi Sulawesi Tenggara.
Ekasari, E., & Dhanny, D. R. (2022). Faktor Yang Mempengaruhi Kadar Glukosa Darah Penderita Diabetes Melitus Tipe Ii Usia 46-65 Tahun Di Kabupaten Wakatobi. Journal of Nutrition College, 11(2), 154–162. https://doi.org/10.14710/jnc.v11i2.32881
El Qahar, H. A. (2020). Pengaruh Lidah Buaya Menurunkan Kadar Glukosa Darah pada Diabetes Melitus Tipe 2. Jurnal Ilmiah Kesehatan Sandi Husada, 12(2), 798–805. https://doi.org/10.35816/jiskh.v12i2.408
Lutfiah, A., & Mellaratna, W. P. (2023). Uji Efektivitas Ekstrak Lidah Buaya (Aloe vera) Dalam Menghambat Pertumbuhan Bakteri Propionibacterium acnes Secara In Vitro The Effectiveness Test of Aloe vera Extract In Inhibiting The Growth of Propionibacterium acnes Bacteria In Vitro. 6(2).
Marzel, R., Darwis, I., & Windarti, I. (t.t.). Ekstrak Lidah Buaya (Aloe Vera) Menurunan Kadar Glukosa Darah pada Diabetes yang diinduksi Streptozotocin pada Tikus Putih (Rattus Norvegicus).
Muliawan, I. K. D. I. (2019). Efek pemberian kombinasi jus aloe vera dan glibenklamid terhadap penurunan kadar glukosa darah pada model tikus diabetes yang diinduksi dengan streptozotosin dan nikotinamid. Intisari Sains Medis, 10(2). https://doi.org/10.15562/ism.v10i2.532
Munjiati, N. E. (2021). Pengaruh Pemberian Streptozotocin Dosis Tunggal terhadap Kadar Glukosa Tikus Wistar (Rattus norvegicus). Meditory : The Journal of Medical Laboratory, 9(1), 62–67. https://doi.org/10.33992/m.v9i1.1330
Mustofa, E. E., & Purwono, J. (2022). Penerapan Senam Kaki Terhadap Kadar Glukosa Darah Pada Pasien Diabetes Melitus Di Wilayah Kerja Puskesmas Purwosari Kec. Metro Utara Tahun 202. 2.
Putri, V. D., Sahlan, S. S., Nuraeni, R., Sari, S. P., & Cahyati, Y. (2022). Pengaruh Pemberian Lidah Buaya (Aloe Vera) Terhadap Penurunan Kadar Gula Darah Pada Penderita Diabetes Mellitus Tipe Ii: Literatur Review. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi, 22(1), 84. https://doi.org/10.36465/jkbth.v22i1.906
Ratu, A. P., Sulastri, L., & Siregar, N. D. (t.t.). Aktivitas Antidiabetes Rebusan Daun Kersen (Mutingia Calabura L.) Dan Daun Teh Hijau (Camellia Sinensis) Serta Kombinasinya Pada Mencit Jantan.
Rahmawati, R., Fatmawati, A., Nurhidayat, N., & Rahmi, A. (2023). Deskripsi Kadar Gula Darah Dan Tingkat Pengetahuan Masyarakat Di Desa Pimpinga Desa Baturappe Kecamatan Biringbulu Kabupaten Gowa. Lontara Abdimas: Jurnal Pengabdian Kepada Masyarakat, 4 (1), 20-28.
Rosares & Boy. (2022). Pemeriksaan Kadar Gula Darah untuk Screening Hiperglikemia dan Hipoglikemia. Jurnal Implementa Husada, 3(2). https://doi.org/10.30596/jih.v3i2.11906
Setiadi, E., Peniati, E., & Susanti, R. (2020). Pengaruh Ekstrak Kulit Lidah Buaya Terhadap Kadar Gula Darah Dan Gambaran Histopatologi Pankreas Tikus Yang Diinduksi Aloksan.
Sopiah, P., & Astuti, A. P. K. (2024). Systematic Review: Perbandingan Lidah Buaya Dan Daun Kersen Dalam Menurunkan Kadar Gula Darah Penderita Diabetes Melitus.
Suwandi, E., Muarofah, S. N., & Slamet, S. (2021). Pengaruh Ekstrak Etanol Daun Simpur Terhadap Kadar Gula Darah Mencit Metode In Vivo. Jurnal Laboratorium Khatulistiwa, 5(1), 13. https://doi.org/10.30602/jlk.v5i1.948
Wanadiatri, H. (2018). Pengaruh Ekstrak Etanol Lidah Buaya (Aloe Vera) Terhadap Glukosa Darah Tikus Hiperglikemia- Terinduksi Streptozotocin. Jurnal Biosains Pascasarjana, 20(1), 33. https://doi.org/10.20473/jbp.v20i1.2018.33-41
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2025 Nurul Hafizah, Harleli Harleli, Renni Meliahsari, Irma Irma
Artikel ini berlisensi Creative Commons Attribution 4.0 International License.
