Andaliman fruit (Zanthoxylum acanthopodium dc) from Sumatera can help reduce blood glucose: Glucose tolerance test
DOI:
https://doi.org/10.54957/ijhs.v6i1.2082Kata Kunci:
Andaliman (Zanthoxylum acanthopodium DC), Antihiperglikemik, Glucose Tolerance Test, One-Way ANOVAAbstrak
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action. The utilization of natural products as antihyperglycemic agents continues to be explored, including andaliman fruit (Zanthoxylum acanthopodium DC.), an endemic plant from Sumatra known to contain bioactive compounds such as flavonoids and saponins. This study aimed to evaluate the antihyperglycemic potential of ethanolic extract of andaliman fruit using an oral glucose tolerance test in male mice. An experimental design was applied with three groups: negative control (distilled water), positive control (glibenclamide), and ethanolic extract of andaliman fruit at a dose of 20 mg/kgBW. Blood glucose levels were measured before and after glucose induction up to 90 minutes. Data were analyzed using One Way ANOVA followed by the Bonferroni post hoc test. The results demonstrated a significant difference among treatment groups (F(2,6) = 19.344; p = 0.002). Post hoc analysis revealed that the andaliman extract significantly differed from the negative control (p = 0.024), but showed no significant difference compared to glibenclamide (p = 0.196). In conclusion, the ethanolic extract of andaliman fruit exhibits antihyperglycemic potential with statistically comparable effectiveness to glibenclamide in a glucose tolerance model. These findings support further development of andaliman as a potential phytopharmaceutical antidiabetic agent derived from local natural resources.
Referensi
Akuba, J., Djuwarno, E. N., Hiola, F., Pakaya, M. S., & Abdulkadir, W. (2022). Efektivitas Penurunan Kadar Glukosa Darah Daun Lamtoro (Leucaena leucocephala L.) Pada Mencit Jantan (Mus muscullus L.). Journal Syifa Sciences and Clinical Research, 4(1).
Basundoro, P. A., dan Adhipireno, P. (2017). Hubungan Kadar Glukosa Darah Terhadap Estimasi Laju Filtrasi Glomerulus Pada Pasien Diabetes Melitus. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro), 6(2).
Fajarwati, I., Solihin, D. D., Wresdiyati, T., & Batubara, I. (2023). Self-recovery in diabetic Sprague Dawley rats induced by intraperitoneal alloxan and streptozotocin. Heliyon, 9(5). https://doi.org/10.1016/j.heliyon.2023.e15533
Haryanti, W. (2021). Pengaruh Media Dua Dimensi Terhadap Pemahaman Konsep Matematika Pada Materi Bangun Datar Siswa Kelas IV SD Negeri 09 Seluma. In Skripsi.
Hilma, R., Gustina, N., & Syahri, J. (2020). Pengukuran Total Fenolik, Flavonoid, Aktivitas Antioksidan dan Antidiabetes Ekstrak Etil Asetat Daun Katemas (Euphorbia heterophylla, L.) Secara In Vitro dan In Silico Melalui Inhibisi Enzim α-Glukosidase. ALCHEMY Jurnal Penelitian Kimia, 16(2). https://doi.org/10.20961/alchemy.16.2.40087.240-249
Irawan, M, R., S, G., Elly, Abbas, Rahmawati, & Mulki. (2022). Review: Mekanisme Molekuler Obat Glibenklamid (Obat Anti Diabetes Tipe-2) Sebagai Target Aksi Obat Kanal Ion Kalium. Jurnal Pendidikan Dan Konseling, 4.
Kim, T. K. (2017). Understanding one-way anova usinKim, T. K. (2017). Understanding one-way anova using conceptual figures. Korean Journal of Anesthesiology, 70(1), 22–26. https://doi.org/10.4097/kjae.2017.70.1.22g
Lestari, D., Lestari, I., dan Sani K, F. (2021). Uji Efektifitas Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) sebagai Antihiperglikemia Terhadap Mencit Putih Jantan Yang Diinduksi Sukrosa. Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan, 7(1).
Lucier, J., & Mathias, P. M. (2024). Type 1 Diabetes. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK507713/
Munjiati, N. E. (2021). Pengaruh Pemberian Streptozotocin Dosis Tunggal terhadap Kadar Glukosa Tikus Wistar (Rattus norvegicus). Meditory: The Journal of Medical Laboratory, 9(1). https://doi.org/10.33992/m.v9i1.1330
Napitupulu, F. I. R., Wijaya, C. H., Sulistiyani, Prangdimurti, E., Akyla, C., Yakhin, L. A., & Indriyani, S. (2020). Comparison of several processing methods in preserving the flavor properties of andaliman (Zanthoxylum acanthopodium dc.) fruit. Journal of Engineering and Technological Sciences, 52(3). https://doi.org/10.5614/j.eng.technol.sci.2020.52.3.7
Pradana, D. B. P., & Harimurti, R. (2017). Pengaruh Penerapan Tools Google Classroom pada Model Pembelajaran Project Based Learning terhadap Hasil Belajar Siswa. IT-Edu: Jurnal Information Technology and Education, 2(01).
Nur Rizky, A., Sukarya, I. G. A., & Kusumawati, N. (2023). The Effect of Giving Ketepeng (Cassia Alata L) Leaves on Allergic Mice (Mus Musculus) Skin Eosinophils. Formosa Journal of Science and Technology, 2(9). https://doi.org/10.55927/fjst.v2i9.5843
Silalahi, M., Purba, E. C., & Mustaqim, W. A. (2018). Tumbuhan Obat Sumatera Utara Jilid II. Journal of Materials Processing Technology, 1(1).
Sinata, N., Pratiwi, I. D., & Muhtadi, W. K. (2023). Uji aktivitas antidiabetes infusa daun salam (Syzygium polyanthum (Wight) Walp.) terhadap kadar glukosa darah mencit putih (Mus Musculus L.) jantan yang diinduksi glukosa. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 4(1), 33-40.
Sintia, I., Pasarella, M. D., & Nohe, D. A. (2022). Perbandingan tingkat konsistensi uji distribusi normalitas pada kasus tingkat pengangguran di Jawa. Prosiding Seminar Nasional Matematika, Statistika, Dan Aplikasinya.
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B.B., Stein, C., Basit, A., Chan, J.C., Mbanya, J.C. dan Pavkov, M.E., 2022. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes research and clinical practice, 183, p.109119.
Tanessa, M., Chiuman, L. dan Kotsasi, F., 2023. Effectiveness Of Andaliman Extract Nanoemulsion (Zanthoxylum Acanthopodium Dc) Against Lipid Profile In Streptozotocin-Induced Wistar Male Rats (Stz). Journal Health & Science: Gorontalo Journal Health and Science Community, 7(1), pp.27-34.
Tanessa, M., P, G. A. P., Chiuman, L., & Kotsasi, F. (2023). Effectiveness Of Andaliman Extract Nanoemulsion (Zanthoxylum acanthopodium Dc) Against Lipid Profile In Streptozotocin-Induced Wistar Male Rats (Stz). Journal Health & Science: Gorontalo Journal Health and Science Community, 7(1). https://doi.org/10.35971/gojhes.v7i1.17387
Ulfa, R., Maddu, A., Darusman, H. S., & Santoso, K. (2020). Gambaran leukosit setelah pemberian nanoenkapsulasi andaliman (Zanthoxylum acanthopodium DC.) pada burung puyuh pascainduksi imunosupresan deksametason. Jurnal Veteriner, 21(2).
World Health Organization. (2023). Diabetes. URL: https://www.who.int/news-room/fact-sheets/detail/diabetes Diakses tanggal 4 November 2024.
Unduhan
Diterbitkan
Cara Mengutip
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2026 Mutia Salsabila Rosyianti, Isyah Radhiyah Saidek, Nindya Nur Amalina, Regalita Novia, Dhigna Luthfiyani Citra Pradana
Artikel ini berlisensi Creative Commons Attribution 4.0 International License.
