Peran Mangiferin Sebagai Inhibitor Enzim Kolagenase Dan Elastase
DOI:
https://doi.org/10.54957/ijhs.v1i1.41Kata Kunci:
mangiferin, antiaging, inhibitor kolagenase, inhibitor etalaseAbstrak
Reactive Oxygen Species (ROS) mampu menyebabkan penuaan dini dengan cara menghilangkan elastisitas kulit sehingga kulit menjadi keriput, kendur, dan mengalami pigmentasi. ROS dapat meningkatkan ekspresi enzim-enzim proteinase seperti matriks metaloproteinase (MMPs) dan protease serin. Enzim tersebut bertanggung jawab dalam mendegradasi kolagen dan elastin yang merupakan komponen protein dalam matriks ekstraselular (ECM) yang berperan dalam menunjang struktur dan sifat fisik kulit. Mangiferin telah terbukti aktivitasnya sebagai antioksidan dengan mengurangi kelebihan ROS didalam sel. Penelitian ini merupakan literatur review peran mangiferin menghambat kerja enzim kolagenase dan elastase yang menyebabkan kerusakan kolagen dan elastin sehingga tanda tanda penuaan dapat dicegah.
Referensi
Aslam, M. N., Lansky, E. P., & Varani, J. (2006). Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. Journal of Ethnopharmacology, 103(3), 311–318. https://doi.org/10.1016/j.jep.2005.07.027
Bartoszewski, R., Hering, A., Marszałł, M., Hajduk, J. S., Bartoszewska, S., Kapoor, N., Kochan, K., & Ochocka, R. (2014). Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts. PLoS ONE, 9(3). https://doi.org/10.1371/journal.pone.0092128
Ferreira, F. da R., Valentim, I. B., Ramones, E. L. C., Trevisan, M. T. S., Olea-Azar, C., Perez-Cruz, F., de Abreu, F. C., & Goulart, M. O. F. (2013). Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin. LWT - Food Science and Technology, 51(1), 129–134. https://doi.org/10.1016/j.lwt.2012.09.032
Gold-Smith, F., Fernandez, A., & Bishop, K. (2016). Mangiferin and cancer: Mechanisms of action. Nutrients, 8(7), 16–20. https://doi.org/10.3390/nu8070396
Iyer, S., Visse, R., Nagase, H., & Acharya, K. R. (2006). Crystal Structure of an Active Form of Human MMP-1. Journal of Molecular Biology, 362(1), 78–88. https://doi.org/10.1016/j.jmb.2006.06.079
Jenkins, G. (2002). Molecular mechanisms of skin ageing. Mechanisms of Ageing and Development, 123(7), 801–810. https://doi.org/10.1016/S0047-6374(01)00425-0
Kacem, R. (2013). Phenolic compounds from medicinal plants as Natural anti-elastase products for the therapy of pulmonary emphysema. Journal of Medicinal Plants Research, 7(48), 3499–3507. https://doi.org/10.5897/JMPR12.865
Ochocka, R., Hering, A., Stefanowicz-Hajduk, J., Cal, K., & Barańska, H. (2017). The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes. PLoS ONE, 12(7), 1–16. https://doi.org/10.1371/journal.pone.0181542
Pardo-Andreu, G. L., Cavalheiro, R. A., Dorta, D. J., Naal, Z., Delgado, R., Vercesi, A. E., & Curti, C. (2007). Fe(III) shifts the mitochondria permeability transition-eliciting capacity of mangiferin to protection of organelle. Journal of Pharmacology and Experimental Therapeutics, 320(2), 646–653. https://doi.org/10.1124/jpet.106.112003
Prado, Y., Merino, N., Acosta, J., Herrera, J. A., Luque, Y., Hernández, I., Prado, E., Garrido, G., Delgado, R., & Rodeiro, I. (2015). Acute and 28-day subchronic toxicity studies of mangiferin, a glucosyl xanthone isolated from mangifera indica l. Stem bark. Journal of Pharmacy and Pharmacognosy Research, 3(1), 13–23.
Shoji, K., Tsubaki, M., Yamazoe, Y., Satou, T., Itoh, T., Kidera, Y., Tanimori, Y., Yanae, M., Matsuda, H., Taga, A., Nakamura, H., & Nishida, S. (2011). Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells. Archives of Pharmacal Research, 34(3), 469–475. https://doi.org/10.1007/s12272-011-0316-8
Stoilova, I., Jirovetz, L., Stoyanova, A., Krastanov, A., Gargova, S., & Ho, L. (2008). Antioxidant activity of the polyphenol mangiferin. Electronic Journal of Environmental, Agricultural and Food Chemistry, 7(2), 2706–2716.
Tamada, T., Kinoshita, T., Kurihara, K., Adachi, M., Ohhara, T., Imai, K., Kuroki, R., & Tada, T. (2009). Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond. Journal of the American Chemical Society, 131(31), 11033–11040. https://doi.org/10.1021/ja9028846
Wahyuningsih, K. A. (2011). Astaxanthin Memberikan Efek Proteksi Terhadap Photoaging. Journal of Medicine, 10(3), 149–160.
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