Gambaran Penggunaan N-Acetyl-L-Cysteine (NAC) Pada Pasien Covid-19 Di RS X Periode Juni-Agustus 2022

Authors

  • Rina Afriani Politeknik Kesehatan Hermina
  • Devi Maulina Politeknik Kesehatan Hermina

DOI:

https://doi.org/10.54957/ijhs.v3i1.422

Keywords:

Gambaran Penggunaan Obat, N-acetyl-L-cysteine (NAC), Covid-19

Abstract

Penyakit Covid-19 merupakan ancaman yang nyata bagi kesehatan di seluruh dunia. Pada kasus Covid-19,        N-acetyl-L-cysteine (NAC) telah digunakan sebagai terapi suportif pengobatan. Penyakit Covid-19 sering dikaitkan dengan ketidakseimbangan oksidan-antioksidan, yang menyebabkan peradangan dan kerusakan jaringan. NAC selain menjadi mukolitik, telah terbukti menjadi antioksidan yang efektif dalam terapi Covid-19. Tujuan dari penelitian ini adalah untuk mengetahui pola penggunaan NAC sebagai terapi pengobatan pada pasien Covid-19 pada pasien rawat jalan di Rumah Sakit X periode Juni-Agustus 2022. Penelitian ini menggunakan metode kuantitatif deskriptif dengan menggunakan data sekunder secara retrospektif. Hasil penelitian dari total 89 sampel pasien yang memenuhi kriteria inklusi didapatkan hasil yaitu berdasarkan kategori usia NAC paling banyak digunakan pada kategori usia dewasa (26-45 tahun) dengan total 46 pasien (51,69%). Berdasarkan jenis kelamin paling banyak terjadi pada pasien dengan jenis kelamin laki-laki dengan total 48 pasien (53,93%). Berdasarkan dosis penggunaan NAC paling banyak digunakan pada dosis 3 x 600 mg secara oral dengan jumlah pasien sebanyak 56 pasien (62,92%). Adapun lama penggunaan NAC yaitu selama 10 hari dengan total 71 pasien (79,78%) dan gejala penyakit yang paling banyak terjadi adalah gejala demam disertai batuk dengan total 55 pasien (61,80%).

 

References

Beltrán-García, J., Osca-Verdegal, R., Pallardó, F. V., Ferreres, J., Rodríguez, M., Mulet, S., Sanchis-Gomar, F., Carbonell, N., & García-Giménez, J. L. (2020). Oxidative stress and inflammation in covid-19-associated sepsis: The potential role of anti-oxidant therapy in avoiding disease progression. Antioxidants, 9(10), 1–20. https://doi.org/10.3390/antiox9100936

Burhan, E., Susanto, A. D., Nasution, S. A., Eka, G., Pitoyo, ceva W., Susilo, A., Firdaus, I., Santoso, A., Juzar, D. A., & Arif, S. K. (2022). Pedoman Tatalaksana COVID-19 Edisi 4. In 4 (Ed.), Pedoman tatalaksana COVID-19 edisi 4. PDPI, PERKI, PAPDI, PERDATIN, IDAI.

Bwire, G. M. (2020). Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women? SN Comprehensive Clinical Medicine, 2(7), 874–876. https://doi.org/10.1007/s42399-020-00341-w

Chen, G., & Lu, H. (2022). Oral high-dose acetylcysteine: Effective against the Omicron variant of severe acute respiratory syndrome coronavirus 2. Drug Discoveries & Therapeutics, 16(3), 139–141. https://doi.org/10.5582/ddt.2022.01032

De Flora, S., Balansky, R., & La Maestra, S. (2020). Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of COVID-19. FASEB Journal, 34(10), 13185–13193. https://doi.org/10.1096/fj.202001807

Du Preez, H. N., Aldous, C., Kruger, H. G., & Johnson, L. (2022). N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19. Advances in Pharmacological and Pharmaceutical Sciences, 2022. https://doi.org/10.1155/2022/4555490

Ekowati, H., Nadzif, F. Q., & Suryoputri, M. W. (2022). Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital Purwokerto , Indonesia. 10, 1–6.

Elgendy, I. Y., & Pepine, C. J. (2020). Why are women better protected from COVID-19: Clues for men? Sex and COVID-19. International Journal of Cardiology, 315, 105–106. https://doi.org/10.1016/j.ijcard.2020.05.026

Hanum, P. S., & Hanifa, Q. (2021). The Effectiveness of High-dose N-acetylcysteine in Severe COVID-19 Patients. KELUWIH: Jurnal Kesehatan Dan Kedokteran, 3(1), 22–34. https://doi.org/10.24123/kesdok.v3i1.4707

Izquierdo-Alonso, J. L., Pérez-Rial, S., Rivera, C. G., & Peces-Barba, G. (2022). N-acetylcysteine for prevention and treatment of COVID-19: current state of evidence and future directions. Journal of Infection and Public Health, 15(12), 1477–1483. https://doi.org/10.1016/j.jiph.2022.11.009

Lacy, C. ., Armstrong, L. ., Goldman, M. ., & Lance, L. . (2009). Drug Information Handbook: A Comprehensive Resource for all Clinicians and Healthcare Professionals 17th Edition (17th ed.). Lexy-Comp’s Americans Pharmacist Associaton.

Maler, F. (2022). Gambaran diagnostik pasien COVID-19 pada usia dewasa di RSU Royal Prima Medan. Jurnal Jambura, 4(1), 475–483.

Putra, A. Z., Pinem, R. W., Silalahi, S., Gulo, F., & Liukhoto, J. A. A. (2022). Classification of Covid-19 Patient Spread Rate By Age and Region With K-Means Algorithm. SinkrOn, 7(3), 1085–1989. https://doi.org/10.33395/sinkron.v7i3.11603

Scaglione, F., & Petrini, O. (2019). Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive? Clinical Medicine Insights: Ear, Nose and Throat, 12, 117955061882193. https://doi.org/10.1177/1179550618821930

Sharma, C., Jha, N. K., Meeran, M. F. N., Patil, C. R., Goyal, S. N., & Ojha, S. (2021). Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19. Frontiers in Pharmacology, 12(June), 1–8. https://doi.org/10.3389/fphar.2021.603997

Shi, Z., & Puyo, C. A. (2020). N-acetylcysteine to combat COVID-19: An evidence review. Therapeutics and Clinical Risk Management, 16, 1047–1055. https://doi.org/10.2147/TCRM.S273700

Sujana, K. S., & Maulida, M. (2021). Efektivitas N-Acetylsistein pada Pasien COVID 19. Cermin Dunia Kedokteran, 48(7), 416. https://doi.org/10.55175/cdk.v48i7.1458

Wong, K. K., Lee, S. W. H., & Kua, K. P. (2021). N-acetylcysteine as adjuvant therapy for covid-19 – a perspective on the current state of the evidence. Journal of Inflammation Research, 14, 2993–3013. https://doi.org/10.2147/JIR.S306849

Zhang, Q., Ju, Y., Ma, Y., & Wang, T. (2018). N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia. Medicine (United States), 97(45). https://doi.org/10.1097/MD.0000000000013087

Published

2023-06-30

How to Cite

Afriani, R., & Maulina, D. (2023). Gambaran Penggunaan N-Acetyl-L-Cysteine (NAC) Pada Pasien Covid-19 Di RS X Periode Juni-Agustus 2022. Indonesian Journal of Health Science, 3(1), 60–68. https://doi.org/10.54957/ijhs.v3i1.422

Issue

Section

Articles

Most read articles by the same author(s)

1 2 3 > >>